MTHFR gene & neuropsychiatric diseases

Methylenetetrahydrofolate reductase (MTHFR) is one of the key enzymes in the metabolism of folate and homocysteine (Hcy), and is involved in the occurrence of neuropsychiatric diseases such as Alzheimer's disease and depression. 


MTHFR-C677T gene mutations cause a decrease in enzyme heat resistance and activity, resulting in a decrease in folate levels, an increase in plasma homocysteine (Hcy) concentration, and damage to central neurons and microvessels, affecting the synthesis of central neurotransmitters and the central nervous system. The methylation of biogenic amines and phospholipids in the nervous system induces many neuropsychiatric diseases such as depression.
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