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Magnafolate®
About US
Knowledge of L-methylfolate
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History & Regulatory Status

History
Regulatory

- 1943

-A scientist Dr.Mitchell from USA extracted around 1mg active folate from four tons of spinach successfully in 1943. However, the chemical property is too active to be stored.

-“How to make the active folate be stable?” has been a global difficulty since 1943.

- 1945

-Folic acid was developed.

-It was a great invention at that time because it's stable enough.
But it's not the best choice with more and more side effects are reported nowdays.

- 1965

-Merck developed 5-methyltetrahydrofolate calcium racemate . CAS.134-35-0

-Racemate is mixed both levorotatory-5-MTHF(what we really need) and Dextral-5-MTHF. D-5-MTHF is not workable.

- 1994

-Merck developed a Pure levorotatory-5-methyltetrahydrofolate calcium Amorphous type. CAS.151533-22-1

-The potency is twicer than racemate 5-MTHF Ca ,but it's still not stable.

- 1999

-Merck developed I crystalline Metafolin® CAS.151533-22-1

-The preparation of the Calcium salt and the crystal type solved the stability problem completely.

- 2012

-Jinkang pharma developed a novel C crystalline Calcium L-5-Methyltetrahydrofolate, called “Magnafolate®” successfully, CAS.151533-22-1

-It's a totally new crystal type independent from Merck's Metafolin®. More uniform and narrow particle size distribution and higher bioavability than Metafolin®.

- 2022

-Jinkang finished the study between Folic acid and Magnafolate® PRO in birth defect

-The paper has been published, if interested, email us info@magnafolate.com

Since L-Methylfolate came out, it has been recognized by various laws and regulations.

- 2001

-The US FDA approved the application of 6S- 5-methyltetrahydrofolate calcium as a new raw material in Nutrition and Health Care Products.

- 2004

-The European Food Safety Authority (EFSA) concluded that 6S-5-methyltetrahydrofolate calcium is safe with the use range of 1 mg / day.

- 2005

-JECFA confirmed 6S-5-methyltetrahydrofolate calcium is safe as folate source.

- 2006

-EU Commission published 2006/34/EC and 2006/37/EC with L-methylfolate

- 2007

-L-methylfolate approved in Switzerland and Norway

- 2009

-Approved in Canada for use in dietary supplements

- 2015

-TGA approval for L-methylfolate in Australia

- 2017

-China National Health and Family Planning Commission approved Magnafolate®6S-5-methyltetrahydrofolate calcium as folate source, used in food supplement.
-Magnafolate® PRO is quality standard in China

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Latest News

Dr. Lian Zengli Takes on Committee Role at Women and Children's Health Conference

Dr. Lian Zengli Takes on Committee Role at Women and Children's Health Conference

Safeguarding Pregnancy Health: How Naturalization Folate Helps Prevent Preeclampsia

Safeguarding Pregnancy Health: How Naturalization Folate Helps Prevent Preeclampsia

Preeclampsia Risk and Early Pregnancy Homocysteine Levels: The Protective Role of 6S-5-Methyltetrahydrofolate

Preeclampsia Risk and Early Pregnancy Homocysteine Levels: The Protective Role of 6S-5-Methyltetrahydrofolate

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