Folic Acid Vs Folate Vs L-5-MTHF Ca

To become metabolically active, folic acid must be converted to dihydrofolate and then tetrahydrofolate which is subsequently converted to the biologically active L-5-Methyltetrahydrofolate by an enzyme called methylenetetrahydrofolate reductase. However, many individuals have a genetic polymorphism in which their methylenetetrahydrofolate reductase enzyme is less active, meaning that they are unable to convert folic acid to L-5-Methyltetrahydrofolate. 
Folic Acid Vs Folate Vs L-5-MTHF Ca
This poses as a problem for folic acid supplementation, as it has been found that in people with this type of polymorphism, folic acid is unable to raise plasma L-5-Methyltetrahydrofolate levels. Calcium salt of L-5 Methyltetrahydrofolate has a great stability profile and it has been shown to be a superior supplement to folic acid as it reduces the potential for masking haematological symptoms of vitamin B12 deficiency (Savage & Lindenbaum, 1994), reduces interactions with drugs that inhibit dihydrofolate reductase and overcomes metabolic defects caused by methylenetetrahydrofolate reductase polymorphism, as well as reducing the potential negative effects of folic acid in peripheral circulation.

Magnafolate  L Methylfolate raw material
Magnafolate L Methylfolate ingredient
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