Folate classification - synthetic folic acid

Because dietary folate is extremely unstable, in 1945 a team led by Dr Yellapragada Subbarow, working in the Lederle laboratory, chemically
The oxidised form of folate, also known as synthetic folic acid, was synthesised.
Product name: Folic acid, also known as vitamin M; vitamin B9;
Chemical name：N-(p-(((2-amino-4-hydroxy-6-pteridinyl)methyl)amino)benzoyl)-L-glutamic acid; PGA; pteglu; 
pteroyl-L-glutamic acid; pteroyl-L-monoglutamic acid; pteroylmonoglutamic acid; 
N-4-[(2-Amido-4-oxo-1,4-dihydro-6-terene) methyl amino] benzoyl-L-glutamic acid;
CAS ： 59-30-3
Chemical formula：
Folate classification - synthetic folic acid
An earlier synthetic route for folic acid was to use nitrobenzoic acid as a raw material through chloroformation - condensation - reduction - cyclisation.
Synthetic folic acid solves the problem of stability of folate, and with its low price, it has quickly become a hot new ingredient in the international health food market.
Magnafolate
However,there are also shortcomings in the long-term use of synthetic folic acid.
After years of work, scientists have developed Magnafolate.
Magnafolate is the unique patent protected C crystalline L-5-Methyltetrahydrofolate Calcium salt (L-5-MTHF Ca) which can get the purest and most stable bio-active folate.
Magnafolate can be absorbed directly, no metabolism, applied for all people.
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