Menopause, defined as the permanent cessation of ovarian function, represents a period of significant fluctuation in sex hormone concentrations. Sex hormones including oestrogen, progesterone, testosterone and anti-Mullerian hormone are thought have neuroinflammatory effects and are implicated in both neuroprotection and neurodegeneration. Sex hormones have a role in modifying clinical trajectory in multiple sclerosis (MS) throughout the lifespan. Low levels of estrogens after menopause stimulate pro-inflammatory pathways and enhance proinflammatory cytokine production, whereas high levels can boost Th-2 anti-inflammatory pathways and humoral immunity. Linking the human menopause to multiple sclerosis. Multiple sclerosis (MS) is a relatively common chronic neurological disorder in which demyelination of axons of neurons occurs in different areas of the central nervous system. The risk of the disease is 3–4 times more in females compared to males. What can we do to improve health and health care of menopausal women? There is a possible link between the onset of the first neurological signs of MS and serum levels of vitamin B12 and folate of the patient at the time. Increasing the consumption of folate and vitamin B12 improved physical and mental dimensions of quality of life.  Scientists have noted an inverse association between unmetabolized folic acid in plasma and NK cell cytotoxicity, suggesting that free folic acid may negatively impact immune function. So using mangafolate as a folate supplement appears to be a better option for menopausal women. Mangafolate is the main biologically active form of folate. Unmetabolized serum folic acid does not arise after consumption of naturally occurring folate.