"Doctor, I've been religiously taking my folic acid supplements, so why does my baby have congenital heart disease?"

"Are you aware that the folic acid you take during pregnancy, If not chosen with care, they could potentially pose a risk

for congenital heart disease. Recent studies have uncovered that folic acid may not always be a protective force but could sometimes be a 'hidden threat' to your baby's heart health."

A study published in the "Cells" journal in 2022 shed light on the impact of folic acid on the early stages of embryonic development.

The findings indicate that folic acid can inhibit blood vessel formation in zebrafish models, leading to cardiovascular malformations and an association with the downregulation of the eif1axb gene, which raises the risk of embryonic mortality. Excessive intake of folic acid by pregnant women may correlate with an increased risk of cardiovascular diseases in infants, particularly congenital heart disease.

However, not all folic acid supplements carry this risk. The study also pointed out that 6S-5-Methyltetrahydrofolate-Calcium (MTHF-Ca) did not show similar cardiac toxicity.

Advantages of 6S-5-Methyltetrahydrofolate-Calcium (MTHF-Ca) Compared to Folic Acid

6S-5-Methyltetrahydrofolate-Calcium (MTHF-Ca) is a metabolic product of folic acid in the body and the main form of human folate. Compared to folic acid, MTHF-Ca is not limited by folate metabolism genes, can be directly absorbed by the body, and effectively avoids the risk of accumulation of unmetabolized folic acid.

Magnafolate: Customized Active Folate for Expectant Mothers

Further in-depth research, scientists have discovered the highest level of active folate, which is also more suitable for humans - naturalization folate. 

As a representative of naturalization folate, Magnafolate does not use toxic and harmful raw materials such as formaldehyde, toluene sulfonic acid, and heavy metals in its production process. At the same time, it uses patented technology to reduce the content of harmful impurities such as JK12A and 5-methyltetrahydropterin to the lowest level, making the product virtually non-toxic, and more suitable for the folate needs of maternal and infant populations.

Conclusion

Every heartbeat is the most beautiful melody of life, telling the miracles and vitality of life. Every choice is a manifestation of our endless love for the baby. In the sacred journey of welcoming new life, every expectant mother is a guardian, building a solid health defense line for the baby with science and care.

Choosing naturalization folate, such as Magnafolate, is not only a responsibility for the heart health of our baby but also a deep expectation for every future growth moment. We believe that love is to give the baby the most secure start, allowing them to grow up in a safe and healthy environment.

Let us join hands in safeguarding our baby's precious first heartbeat, nurturing them through every growth milestone, and celebrating their unique brilliance.

References:

1. Lian Z, Wu Z, Gu R, Wang Y, Wu C, Cheng Z, He M, Wang Y, Cheng Y, Gu HF. Evaluation of Cardiovascular Toxicity of Folic Acid and 6S-5-Methyltetrahydrofolate-Calcium in Early Embryonic Development. Cells. 2022;11:3946. doi:10.3390/cells11243946.

2. Pietrzik K, Bailey L, Shane B. Folic Acid and L-5-Methyltetrahydrofolate: Comparison of Clinical Pharmacokinetics and Pharmacodynamics. Clin Pharmacokinet. 2010;49(8):535-548. doi:10.2165/11532990-000000000-00000.

3. Lian Zenglin, Liu Kang, Gu Jinhua, Cheng Yongzhi, et al. Biological Characteristics and Applications of Folate and 5-Methyltetrahydrofolate. Food Additives in China, 2022 Issue 2.