As we embark on the heartwarming journey of welcoming a new life, a crucial health topic emerges—folate metabolism.

Authoritative data suggests that nearly 78.4% of pregnant mothers in China may encounter obstacles in folate metabolism during pregnancy. This statistic underscores the importance of scientifically supplementing folate during this

critical period.

Folate: The Unsung Hero of Pregnancy Health

Folate, a vital member of the vitamin family, is indispensable for a healthy pregnancy. It quietly guards the health of both mother and child, playing an essential role. It is involved in the development of the fetal nervous system and in DNA synthesis and repair, laying a solid foundation for the baby's healthy growth. However, due to individual differences in maternal health, the absorption and utilization of folate can vary significantly.

Genetic Polymorphism: The Individuality of Folate Metabolism

Various enzymes, such as 5,10-methylenetetrahydrofolate reductase (MTHFR) and methionine synthase reductase (MTRR), participate in the transport and metabolism of folate. These enzymes' genes exhibit polymorphisms, meaning that different individuals may have different genotypes, which can directly affect the efficiency of folate metabolism. For example, certain MTHFR gene variants can increase the risk of folate metabolism issues, potentially raising the risk of birth defects.

MTHFR Polymorphism and Birth Defects

Studies show that when the maternal MTHFR gene is 677TT (homozygous), the risk of neural tube defects increases sixfold, and the risk of Down syndrome increases 2.6 times. Moreover, when the maternal MTHFR gene is 677TT (homozygous) and folate intake is insufficient, the risk of cleft lip and palate increases by 10.1 times.

Naturalization Folate: Overcoming Barriers for Better Absorption

In response to the challenges of folate metabolism, scientists have developed a new type of folate supplement—Naturalization Folate. Unlike traditional folic acid, Naturalization Folate is not hindered by genetic polymorphisms and can be

directly absorbed and utilized by the body, significantly improving folate bioavailability. Opting for Naturalization Folate not only offers a more efficient supplementation strategy for pregnant women but also provides a robust safeguard for the healthy development of the baby.

Guarding Love, Starting with Naturalization Folate

As expectant mothers, every decision we make affects the future of our babies. Supplementing with folate during pregnancy is a commitment to our own health and a nurturing act for our babies' futures. Let us join hands in choosing

Naturalization Folate to lay a solid foundation for our babies' healthy futures.

References:

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2. Botto LD, Yang Q. 5,10-Methylenetetrahydrofolate Reductase Gene Variants and Congenital Anomalies: A HuGE Review. Am J Epidemiol. 2000;151:862-877.

3. van Rooij IALM, Vermeij-Keers C, Kluijtmans LAJ, et al. Does the Interaction between Maternal Folate Intake and the Methylenetetrahydrofolate Reductase Polymorphisms Affect the Risk of Cleft Lip with or without Cleft Palate? Am J Epidemiol. 2003;157:583-591.

4. Christensen KE, Feroz Zada Y, Rohlicek CV, et al. Risk of congenital heart defects is influenced by genetic variation in folate metabolism. Cardiol Young. 2013 Feb;23(1):89-98.

5. Lian Zengli, Liu Kang, Gu Jinhua, Cheng Yongzhi, et al. The Biological Characteristics and Applications of Folate and 5-Methyltetrahydrofolate. Food Additives in China, 2022 Issue 2.

6. Golja MV, Šmid A, Karas Kuželičko N, Trontelj J, Geršak K, Mlinaric-Rašcan I. Folate Insufficiency Due to MTHFR Deficiency Is Bypassed by 5-Methyltetrahydrofolate. J Clin Med. 2020;9:2836.

7. Wilcken B, et al. Geographical and ethnic variation of the 677C>T allele of 5,10 methylenetetrahydrofolate reductase (MTHFR): findings from over 7000 newborns from 16 areas worldwide. J Med Genet. 2003;40:619-625.