As reported in the literature on folic acid, LD50 of rats was 0.5g/kg, that is, when rats were fed at a dose of 0.5g/kg, they were usually poisoned.
Moreover, high dose folic acid not only cause liver burden, but also unmetabolized homocysteine, leading to severe oxidative stress.
Click here to learn the detail: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7509461/
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