"High-dose folic acid supplementation results in significant accumulation of unmetabolized homocysteine, leading to severe oxidative stress in Caenorhabditis elegans "

As reported in the literature on folic acid, LD50 of rats was 0.5g/kg, that is, when rats were fed at a dose of 0.5g/kg, they were usually poisoned. 

Moreover, high dose folic acid not only cause liver burden, but also unmetabolized homocysteine, leading to severe oxidative stress. 

folic acid supplementation

Click here to learn the detail: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7509461/

Magnafolate® ,the Manufacturers & Supplier of active folate -Jinkang

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