With more and more people meet the side effect of folic acid, the active L-methylfolate is more popular used as a new folate source in dietary supplement for prenatal, improving cognition and benefit for depression,etc. L-methylfolate is also called Nature folate, active folate and L-5-methyltetrahydrofolate which has the same chemical structure as the folate in our blood. It’s also the metabolite of folic acid.
However, the questions are coming.
The same CAS.151533-22-1 source, but, big different price between Jinkang pharma and all rest suppliers. Why?
NO.1 STABLE
Jinkang pharma is making the patent protected C crystalline L-5-MTHF Ca of Magnafolate®, while the rest suppliers are making the Amorphous type L-5-MTHF Ca.
L-methylfolate is very sensitive to water and and oxygen. The C crystal form could use its lattice energy to isolate oxygen and water, and then protect L-methylfolate be stable. While, the marketed generic L-methylfolate belongs to amorphous type. It's easy to be oxidized, has very poor stability. You can easy to find the spatial structure difference between the Crystalline and amorphous type from following picture.
NO.2 SAFE
It’s very IMPORTANT. Magnafolate® doesn’t use Formaldehyde such harmful raw material during production process.
All rest marketed L-methylfolate use Formaldehyde.
As a consumer, if you were looking for the most SAFE L-methylfolate supplement, must find “Magnafolate®” on the label.

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