Folate, an essential micronutrient, is a critical cofactor in one-carbon metabolism. Mammals cannot synthesize folate and depend on supplementation to maintain normal levels. Low folate status may be caused by low dietary intake, poor absorption of ingested folate and alteration of folate metabolism due to genetic defects or drug interactions.

Folate deficiency has been linked with an increased risk of neural tube defects, cardiovascular disease, cancer and cognitive dysfunction. So, people are usually recommended intakes of folate through folic acid supplements or fortified foods in many countries.

Currently, the way to supplement folate from external is folic acid and 5-methyltetrahydrofolate.

Well, it has been proved that 5-methyltetrahydrofolate (5-MTHF) has important advantages over folic acid in many studies.  

Firstly, 5-MTHF is well absorbed even when gastrointestinal pH is altered and its bioavailability is not affected by metabolic defects.

Secondly, using 5-MTHF instead of folic acid reduces the potential for masking haematological symptoms of vitamin B12 deficiency, reduces interactions with drugs that inhibit dihydrofolate reductase and overcomes metabolic defects caused by methylenetetrahydrofolate reductase polymorphism.

Thus, 5-MTHF is the right folate source which we should take. Magnafolate, the same form as 5-MTHF, will be your perfect choice.

Magnafolate® ,the Manufacturers & Supplier of active folate.