Clinical application of MTHFR gene polymorphism detection

Infertility outpatient reproductive center
Decreased men's sperm density, recurrent abortion, etiological diagnosis of complex diseases.
The MTHFR C677T genotype increased the risk of male infertility by 2.68 times, and the TT genotype had a 2.96 times higher risk of habitual abortion than the wild type.

Pre-pregnancy education Center
The gene mutation significantly reduced the folic acid conversion ability, which is conducive to the full play of folic acid conversion ability, better maintain the serum folic acid concentration, according to the different genotype, determine the personalized folic acid supplement program.

Obstetrics-Gynecology Department(NTD)
Congenital heart disease, cleft lip and palate, Down syndrome, preeclampsia, gestational hypertension.
MTHFR C677T causes a dramatic increase in the risk of neonatal defects and pregnancy.

Cardiology and Neurology Department
Etiological diagnosis of complex diseases such as hypertension, coronary heart disease and stroke
Patients with hyperhomocysteine and hypertension have a 12-fold increased risk of cerebrovascular disease. MTHFR C677T was an independent predictor of blood homocysteine concentration, coronary heart disease, and stroke.

Brain tumor Department of Medicine 5-FU
Patients with different MTHFR genes have significant responses to 5-FU and other chemotherapy drugs. MTHFR gene polymorphism can affect the efficacy of chemotherapy drugs that need to be metabolized through folic acid pools.

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