Studies have shown that folate deficiency has been linked with an increased risk of neural tube defects, cardiovascular disease, cancer and cognitive dysfunction. Most countries have established recommended intakes of folate through folic acid supplements or fortified foods. External supplementation of folate may occur as folic acid or 5-methyltetrahydrofolate (5-MTHF),etc.

Well, which kind of folate form is real suitable for you? Certainly, 5-MTHF is much safer for us!

5-MTHF has important advantages over folic acid - it is well absorbed directly and its bioavailability is not affected by metabolic defects. Using 5-MTHF instead of folic acid reduces the potential for masking haematological symptoms of vitamin B12 deficiency, reduces interactions with drugs that inhibit dihydrofolate reductase and overcomes metabolic defects caused by methylenetetrahydrofolate reductase polymorphism.