Folate is a vitamin B9 recommended by the World Health Organization (WHO in short) for pregnant women worldwide. It is recommended to start intaking from the time of pregnancy, because the blood concentration of folate can reach the blood concentration of preventing neural tube abnormalities in children after 2-3 months of taking folate from the time of pregnancy. Hence, if you are planning to start pregnancy, taking folate 2--3 months in advance, 400ug per day after meal. Its role, at present, is to prevent neural tube malformation. The prevention of neural tube malformations, including encephaloceles, spina bifida and exposed brain malformations, accounted for the first place in the fetal defects in the past.

Due to the popularity of folate, it has been reduced to a very low level, and its name is no longer in the top ten, which can be seen to be very effective. Second, prevent congenital heart disease. We found a difference in the incidence of congenital heart disease in pregnancy who took folate supplements and those who did not. The third is to prevent cleft lip and palate, because folate supplementation will reduce the occurrence of cleft lip and palate, but congenital heart disease and cleft lip and palate are caused by many factors, it is impossible to take folate to reduce congenital heart disease and cleft lip and palate to zero.