L-5-Methyltetrahydrofolate, most easily abbreviated as 5-MTHF (sometimes L-5-MTHF), is a specific form of folate.
Folate, or vitamin B9, comes in many forms. 10-MTHF, dihydrofolate, tetrahydrofolate, and folic acid are all, in essence, the same thing. The label on a multivitamin will tell you what form of folate it contains.
Each form of folate contains what your body needs -- they merely deliver it in a different way.
Now, methylfolate has been widely used in improving depression.
Unlike folic acid, L-Methylfolate is the only form of folate that can cross the blood-brain barrier to help facilitate the synthesis of the neurotransmitters associated with mood regulation—serotonin, dopamine and norepinephrine. A deficiency in L-Methylfolate has been linked to depression. Also, taking a supplement containing 15mg methylfolate can help fight against depression, with the clinical study supported.
——Magnafolate® ,the Manufacturers & Supplier of active folate -Jinkang(The No.1 manufacture of L-Methylfolate Calcium in China, and No.2 worldwide, with much more experiences in exporting this material to North America, European, Brazil and etc..)