It’s used in supplements and added to processed food products, such as flour and breakfast cereals.
Unlike folate, not all of the folic acid you consume is converted into the active form of vitamin B9 — 5-MTHF — in your digestive system. Instead, it needs to be converted in your liver or other tissues 。
Yet, this process is slow and inefficient in some people. After taking a folic acid supplement, it takes time for your body to convert all of it to 5-MTHF .
Even a small dose, such as 200–400 mcg per day, may not be completely metabolized until the next dose is taken. This problem may become worse when fortified foods are eaten along with folic acid supplements .
As a result, unmetabolized folic acid is commonly detected in people’s bloodstreams, even in the fasted state .
This is a cause for concern, as high levels of unmetabolized folic acid have been associated with several health problems.
However, one study suggests that taking folic acid along with other B vitamins, particularly vitamin B6, makes the conversion more efficient 。
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