The difference between 99% and 97.5% purity of L-methylfolate Ca

Calcium L-5-methyltetrahydrofolate (L-5-MTHF-Ca; CAS No. 151533-22-1) is the calcium salt of L-5- methyltetrahydrofolic acid (L-5-MTHF), which is the predominant naturally occurring folate in foods.The regular marketed L-5- MTHF Ca purity is 97.5%,even though the standard is 95%-102%,meanwhile Magnafolate is above 99%.Magnafolate is the patented trademark of C crystal form L-5-MTHF Ca from Jinkang Hexin Pharmaceutical Company.

Referring to the JECFA and USP,impurities in L-5-MTHF-Ca are of three classes.The first is minor amounts of other folates,includig folic acid,Tetrahydrofolic acid,5,10-Methylenetetrahydrofolic acid.The second is breakdown and oxidation products of L-5-MTHF-Ca,they are 4-Aminobenzoylglutamic acid,5-Methyltetrahydropteroic acid ,4α-Hydroxy-5-methyltetrahydrofolic acid , 2-Amino-8-methyl-4,9-dioxo-7-methyl-p-aminobenzoylglutamate-6,7,8,9-tetra-hydro-4Hpyrazino-(1,2-a)-s-triazine.The third is other products: a diastereoisomer of 5-MTHF and the dimethylated form of tetrahydrofolic acid.Total Impurities should not exceed 2.5% and the (6R)-diastereoisomer of 5-MTHF should not exceed 1%.Besides,chloride,elemental impurities,residual solvents and other items are also taken into consideration.

Study on Magnafolate shows that the chloride content is about 0.004% while the standard is no more than 0.5%.D-5 methylfolate and 4α-Hydroxy-5-methyltetrahydrofolic acid are both around 0.1% while the standard is 1%.Besides,4-Aminobenzoylglutamic acid, folic acid,Tetrahydrofolic acid,5,10-Methylenetetrahydrofolic acid are all not detected even the standard is 0.5%.So What's the real difference between 99% and 97.5% except for better purity?

The answer is the advanced unique C type crystallization technology.Magnafolate is the invented crystal form Ca L-5MTHF with 61 patent protection globally.The stable structure leads to less compound impurities and gives better appearance.

The answer is better and more strict production process.Magnafolate avoid using any potential toxic substances such as formaldehyde and platinum during production process.All the potential risky impurity are controlled into the smallest assay.

purity of L-methylfolate Ca
The answer is high social responsibility and vision lead Magnafolte’s innovation and urge all to invent,produce and provide the most pure and safe product to humans with helping their wellness and fitness generation to generation.

As we all know,babies are very sensitive to toxic substances during the implantation period of fertilized eggs, so the requirement of the purity of raw materials for the prenatal is supreme high.The safe development of infancy will have an impact on the whole life cycle in the future and can even affect 3 generations.From this perspective,purity between 99% and 97.5% makes big difference and high purity 99% is always the first choice.

All in all,the difference between 99% and 97.5%,reflects the pursuit of excellent product,the embodiment of the scientific and technological strength,the sense of responsibility to minimize the potential risk and the infinite care for human health.


Magnafolate® ,the Manufacturers & Supplier of purest L-methylfolate Ca.

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