L-Methylfolate VS folate

Because the body cannot produce folate, people rely on diet to achieve the levels required for optimal health, especially during pregnancy. However, folate is a general term used to identify a wide range of water-soluble B vitamins, including reduced folate naturally present in foods, and oxidative synthetic folate in supplements and fortified foods. In order to create better folate based pregnancy products, it is important to understand the correct type of folate required.

In vivo, the body converts dietary folate and food folate into 5-MTHF (also known as l-methylfolate or 5-methyltetrahydrofolate) through a multi-step process, in which methylenetetrahydrofolate reductase (MTHFR) plays a key role. However, unlike food folate, folate must first be reduced to tetrahydrofolate by a two-step reaction of dihydrofolate reductase (DHFR), and then further metabolized.
L-Methylfolate VS folate
Due to the unique genetic pattern and expression, MTHFR enzyme activity decreased in some individuals. They have the polymorphism of this enzyme, which is related to the decrease of plasma level of bioactive 5-MTHF folate. Active folate supplementation may help to ensure that people have the same folate contribution without having a genetic impact on bioavailable blood folate. This directly provides the mother and fetus with folate with nutritional activity.

Magnafolate® maximizes the folate supplementation delivering a "finished" folate the body can immediately use without any kind of metabolization.

Magnafolate® ,the Manufacturers & Supplier of active folate(L-Methylfolate).
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