The difference between the two is how they are used by the body.
Folate is converted into the active form of vitamin B9 in the digestive tract, called 5-methyl-thf (5-MTHF).
Folic acid needs to enter the blood and be transported to the liver and other tissues to convert to 5-MTHF. This is a slow and inefficient process, and most of the folate is not metabolized and circulates freely in the body.
About 30-40% of the population may have MTHFR genetic defects, which will impair the conversion of folic acid to active folate.
Although high levels of circulating folate do not harm most people, some people believe that high levels may increase the risk of prostate cancer.
In terms of prostate cancer risk, men who continue to take 1000 micrograms or more of folic acid seem to face the greatest potential risk. On the other hand, men who ate enough folate in their diet had a lower risk.
Despite these shortcomings, folic acid is cheap and non-toxic, and is unlikely to cause side effects unless overdosed.
So we recommend:
Magnafolate® L-Methylfolate—maximizes the supplementation delivering a "finished" folate the body can immediately use without any kind of metabolization.
Jinkang Pharma ,the Manufacturer & Supplier of L-Methylfolate.